GIFT4 fusokine converts leukemic B cells into immune helper cells
نویسندگان
چکیده
منابع مشابه
Engineered fusokine GIFT4 licenses the ability of B cells to trigger a tumoricidal T-cell response.
Engineered chimeric cytokines can generate gain-of-function activity in immune cells. Here, we report potent antitumor activity for a novel fusion cytokine generated by N-terminal coupling of GM-CSF to IL4, generating a fusokine termed GIFT4. B cells treated with GIFT4 clustered GM-CSF and IL4 receptors on the cell surface and displayed a pan-STAT hyperphosphorylation associated with acquisitio...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2016
ISSN: 1479-5876
DOI: 10.1186/s12967-016-0865-1